William Spencer Hurst,Kent Alan Williams,Donald A. Smith,Michael P. Wehrli,Luis Ernesto Criales Escobar,Jessica Tam,Joseph Edward Bigalke,Gert Najdeni,Karan Kerwell,Lushan Zhou,Michael Imeobong Essien
申请号：
US16392074
公开号：
US20190329196A1
申请日:
2019.04.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.
