HONG, KEELUNG,KAO, HAO-WEN,LIN, YI-YU,GUO, LUKE S. S.
申请号：
CA3073734
公开号：
CA3073734A1
申请日:
2018.08.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Provided is an anesthetic composition for locally administrating an amide-type anesthetic into a subject in need thereof. The anesthetic composition has multilamellar vesicles with en trapped amide-type anesthetic prepared by hydrating a highly entrapped lipid structure comprising an amide-type anesthetic and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more feasible process for large-scale manufacture and for providing a high molar ratio of amide-type anesthetic to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
