Disclosed is a composition comprising a pyrazino-triazine derivative, an isomer thereof or a pharmaceutically acceptable salt thereof. It is very effective for preventing and treating NSCLC.本發明揭示一種包含吡嗪并三嗪衍生物、其異構體或其醫藥學上可接受之鹽之組成物。其能極有效預防及治療非小細胞肺癌(NON-SMALL CELL LUNG CANCER,NSCLC)。