The present disclosure provides a method for the generation of 223Ra of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra； ii) loading said generator mixture onto a strong base anion exchange resin； iii) eluting said 223Ra from said strong base anion exchange resin using a first mineral acid in an alcoholic aqueous solution to give a first eluted 223Ra solution； iv) loading the 223Ra of the first eluted 223Ra solution onto a strong acid cation exchange resin； and v) eluting the 223Ra from said strong acid cation exchange resin using a second mineral acid in aqueous solution to provide a second eluted solution.
