MANTZILAS, Dimitrios,KARLSON, Jan Roger,ØSTBY, Judit Tjelmeland
申请号：
SG11201805459U
公开号：
SG11201805459UA
申请日:
2016.12.29
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
The present invention comprises a method for the generation of 227Th of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra； ii) loading said generator mixture onto a strong base anion exchange resin； iii) eluting a mixture of said 223Ra and 227Ac from said strong base anion exchange resin using a first mineral acid in an aqueous solution； iv) eluting 227Th from said strong base anion exchange resin using a second mineral acid in an aqueous solution whereby to generate a first 227Th solution containing contaminant 223Ra and 227Ac； v) loading the first 227Th solution onto a strong acid cation exchange resin； vi) eluting at least a part of the contaminant 223Ra and 227Ac from said strong acid cation exchange resin using a third mineral acid in aqueous solution； and vii) eluting the 227Th from said strong acid cation exchange resin using a first aqueous buffer solution to provide a second 227Th solution. Purified thorium-227 of pharmaceutical purity and a pharmaceutical composition comprising the same are also provided.
