DOOLEY, KEVIN P.,MCCONNELL, RUSSELL E.,XU, KE,HOUDE, DAMIAN,ROSS, NIKKI,HAUPT, SONYA,KULMAN, JOHN D.,WILLIAMS, DOUGLAS E.,HARRISON, RANE A.
申请号：
CA3072352
公开号：
CA3072352A1
申请日:
2018.08.24
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.
