A method for administration of botulinum toxin, includes the steps of (a) selecting at least one neuromuscular blocking agent having a duration of activity shorter than neuromuscular blocking activity of botulinum toxin (b) selecting at least one muscle of a muscle group (c) intramuscularly injecting the selected agent into the selected muscle (d) observing muscle relaxation in both the selected muscle and other nonselected muscles in the muscle group to determine spill-over, muscle tone and balance (e) repeating steps (b)-(d) until a final muscle selection is found and (f) intramuscularly injecting botulinum toxin into the final muscle selection.
