ENHANCING THE T-CELL STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS IN VITRO AND IN VIVO AND THEIR USE IN VACCINATION

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专利权人:

Kris Maria Magdalena Thielemans;Aude Bonehill

发明人:

Kris Maria Magdalena Thielemans,Aude Bonehill

申请号：

US13593393

公开号：

US20130108663A1

申请日:

2012.08.23

申请国别(地区):

US

年份:

2013

代理人:

摘要：

New methods of in vitro or in vivo enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and the use thereof in cancer vaccination are provided. The method includes introduction of different molecular adjuvants to human DCs by contacting or modifying them with mRNA or DNA molecule(s) encoding CD40L, and CD70 or constitutively active TLR4 (caTLR4).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/