ENHANCING THE T-CELL STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS IN VITRO AND IN VIVO AND ITS USE IN VACCINATION

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专利权人:

Vrije Universiteit Brussel

发明人:

Kris Maria Magdalena Thielemans,Aude Bonehill

申请号：

US15843177

公开号：

US20180133311A1

申请日:

2017.12.15

申请国别(地区):

US

年份:

2018

代理人:

摘要：

We provide new methods of in vitro or in vivo enhancing the T-cell stimulatory capacity of human DCs and the use thereof in cancer vaccination. The method includes the introduction of different molecular adjuvants to human DCs by contacting or modifying them with mRNA or DNA molecule(s) encoding CD40L, and CD70 or constitutively active TILR4 (caTLR4).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/