INHIBITORS OF BETA-SECRETASE

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专利权人:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH;VITAE PHARMACEUTICALS, INC.

发明人:

BUKHTIYAROV, YURI,CACATIAN, SALVACION,DILLARD, LAWRENCE WAYNE,DORNER-CIOSSEK, CORNELIA,FUCHS, KLAUS,JIA, LANQI,LALA, DEEPAK S.,MORALES-RAMOS, ANGEL,RAST, GEORG,REEVES, JONATHAN,SINGH, SURESH B.,VENKAT

申请号：

RSP20160246

公开号：

RS54730B1

申请日:

2013.03.04

申请国别(地区):

RS

年份:

2016

代理人:

摘要：

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.Jedinjenje predstavljeno strukturnom formulom izabranom između:ili njegova farmaceutski prihvatljiva so.Prijava sadrži još 13 patentnih zahteva.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/