Yuri Bukhtiyarov,Salvacion Cacatian,Lawrence Wayne Dillard,Cornelia Dorner-Ciossek,Klaus Fuchs,Lanqi Jia,Deepak S. Lala,Angel Morales-Ramos,Jonathan Reeves,Suresh B. Singh,Shankar Venkatraman,Zhenrong
申请号：
US15383287
公开号：
US09949975B2
申请日:
2016.12.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
