Brian W. Metcalf;Yingxin Zhang;Amy Qi Han;Darius J. Robinson;Anlai Wang;Chu-Biao Xue;Changsheng Zheng
发明人:
Chu-Biao Xue,Brian W. Metcalf,Amy Qi Han,Darius J. Robinson,Changsheng Zheng,Anlai Wang,Yingxin Zhang
申请号：
US12274045
公开号：
US08697870B2
申请日:
2008.11.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula I:(wherein R1, R2, R3, R4, R5, R6, R7, X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
