Ganfeng Cao;Brian W. Metcalf;Darius J. Robinson;Amy Qi Han;Taisheng Huang;Chu-Biao Xue;Hao Feng;Changsheng Zheng
发明人:
Chu-Biao Xue,Brian W. Metcalf,Hao Feng,Ganfeng Cao,Taisheng Huang,Changsheng Zheng,Darius J. Robinson,Amy Qi Han
申请号：
US13162286
公开号：
US08362003B2
申请日:
2011.06.16
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to 3-aminopyrrolidine derivatives of the formula I:(wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as a modulator of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
