SHIN, YOUNG GYUN,신영균,JEONG, WON TAEK,정원택,KIM, KWAN HEE,김관희,CHOI, TAE GUN,최태근
申请号：
KR1020120008215
公开号：
KR1020130087153A
申请日:
2012.01.27
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A method for preparing rosuvastatin is provided to obtain a large amount of high purity rosuvastatin using an intermediate compound without a separate purification process.CONSTITUTION: An intermediate compound is denoted by chemical formula 1. A method for preparing the intermediate compound comprises the steps of: reacting a compound of chemical formula 2 with a phosphine-based compound to prepare a compound of chemical formula 3 and reacting the compound of chemical formula 3 with a compound of chemical formula 4 under the presence of a base. A method for preparing a rosuvastatin compound of chemical formula 6 or a pharmaceutically acceptable salt thereof comprises the steps of: deprotecting the intermediate compound of chemical formula 1 under the presence of acid hydrolyzing the treated compound under the presence of a base and neutralizing and reacting with a pharmaceutically acceptable salt.COPYRIGHT KIPO 2013본 발명은 로수바스타틴의 제조방법 및 이에 사용되는 중간체 화합물에 관한 것으로서, 상기 제조방법은 하기 화학식 1의 구조를 갖는 중간체 화합물을 이용함으로써 온화한 반응 조건에서 별도의 정제 공정 없이도 고순도의 로수바스타틴을 고수율로 제조할 수 있다:[화학식 1]상기 식에서, R1 및 M은 명세서 중에서 정의한 바와 같다.
