Andrea L. C. Robidoux,David Bebbington,David J. Lauffer,David J. Livingston,Guy W. Bemis,Julian M. C. Golec,Keith P. Wilson,M. Woods Wannamaker,Mark A. Murcko,Mark J. Batchelor,Michael D. Mullican,Mic
申请号：
BRPI9612258
公开号：
BRPI9612258B8
申请日:
1996.12.20
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
"Interleukin-1beta converting enzyme inhibitors". The present invention relates to novel classes of compounds that are enzyme inhibitors converting interleukin 1Î ±. The ice inhibitors of this invention are characterized by specific structural and physicochemical aspects. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ice activities and therefore may advantageously be used as agents against IL-1, apoptosis, IgIF, and IFN-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to processes for inhibiting ice activity, for treating interleukin-1, apoptosis, igif and ifn-γ-mediated diseases, and decreasing the production of igif and ifn-γ using the compounds and compositions of this invention. invention. This invention also relates to processes for preparing n-acylamino compounds.patente de invenção: <；b>；"inibidores de enzima convertendo interleucina-1beta"<；d>；. a presente invenção refere-se a novas classes de compostos que são inibidores de enzima convertendo interleucina 1<；225>；. os inibidores de ice desta invenção são caracterizados por aspectos estruturais e fisicoquímicos específicos. esta invenção também se refere a composições farmacêuticas compreendendo estes compostos. os compostos e composições farmacêuticas desta invenção são particularmente bem apropriadas para inibir a atividades ice e consequentemente podem ser usados com vantagem como agentes contra doenças mediadas por il-1, apoptose, igif, e ifn-~ y~, doenças inflamatórias, doenças autoimunes, distúrbios destrutivos de ossos, distúrbios proliferativos, doenças infecciosas, doenças degenerativas, e doenças necróticas. esta invenção também se refere a processos para inibir a atividade ice, pa
