Chengbin Wu;Dominic J. Ambrosi;Renee Miller;Chung-ming Hsieh
发明人:
Chengbin Wu,Chung-ming Hsieh,Renee Miller,Dominic J. Ambrosi
申请号：
US12905499
公开号：
US08398966B2
申请日:
2010.10.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
