This invention relates to substituted bicyclic dihydropyrimidinones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.本發明係關於式1之經取代雙環二氫嘧啶酮及其作為嗜中性白血球彈性酶活性之抑制劑的用途，含有其之醫藥組合物，及使用其作為藥劑以治療及/或預防肺、胃腸及泌尿生殖疾病、皮膚及眼之發炎疾病以及其他自體免疫及過敏病症、同種異體移植排斥及致癌疾病的方法。
