The present invention relates to substituted 4-pyridones of formula 1 below and their use as neutrophil elastase activity inhibitors, pharmaceutical compositions containing them, as well as lung diseases, gastrointestinal diseases and genitourinary diseases, The present invention relates to inflammatory diseases of the skin and eyes and other autoimmune and allergic disorders, allograft rejection, and their use as agents for the treatment and / or prevention of oncological diseases. [Selection figure] None本発明は、下記式1の置換4-ピリドン【化１】1及びそれらの好中球エラスターゼ活性阻害薬としての使用、それらを含有する医薬組成物、並びに肺疾患、胃腸疾患及び尿生殖器疾患、皮膚及び眼の炎症性疾患並びに他の自己免疫及びアレルギー障害、同種移植片拒絶、及び腫瘍学的疾患の治療及び／又は予防用薬剤としてのそれらの使用方法に関する。【選択図】なし
