The invention in through the hollow microstructures (Hollow microstructure) square drug delivery method, biocompatible / biodegradable electroporation with microstructures (Biodegradable microstructure) sustained release drug delivery methods and solid microstructures (Solid microstructure) through It will be integrated by the (Electroporation) on the multi-functional hybrid microstructures (Multi-functional hybrid microstructure), and a method of producing at the same time to implement the functions of the micro-structure and improving the efficiency of percutaneous administration drug.Hybrid microstructures, biocompatible, biodegradable, solid, hollow, micro-needles, micro-spikes, electroporation, drug delivery, multi-functional본 발명은 중공형 마이크로구조체(Hollow microstructure)를 통한 속방형 약물전달 방법, 생체적합성/생분해성 마이크로구조체(Biodegradable microstructure)를 통한 서방형 약물전달 방법 및 솔리드 마이크로구조체(Solid microstructure)를 통한 전기 천공법(Electroporation)을 집적하여 각 마이크로구조체의 기능을 동시에 구현하고 약물의 경피 투여 효율을 향상시키는 다기능 하이브리드 마이크로구조체(Multi-functional hybrid microstructure) 및 그의 제조방법에 관한 것이다.