LIU, HAO LI,刘浩澧,劉浩澧,WEI, KUO CHEN,魏国珍,魏國珍,CHEN, PIN YUAN,陈品元,陳品元,HSU, PO HUNG,许博泓,許博泓,CHU, PO CHUN,朱伯骏,朱伯駿,CHAI, WEN YEN,柴雯燕,柴雯燕,LIN, CHUNG YIN,林中英,林中英
申请号：
TW104131099
公开号：
TWI562801B
申请日:
2015.09.21
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.本發明揭露一種利用醫學影像監控,以超音波作為傳遞媒介之分子通透中樞神經系統的方法,是基於醫學影像的觀察預測分子通透量的兩階處理法。第一階旨在於統一建立一種均一曝照之指標,進而建立一個對影像參數的轉換關係,第二階旨在於以一種均一的影像參數使成像輸出結果均一,以建立一個可靠的分子濃度轉換關係。連結第一階和第二階,即可以藉由超音波曝照條件和分子量,測定被超聲輻射誘導的分子通透量。100、102、104、106、108、110、112、114‧‧‧步驟
