Hao-Li Liu,Kuo-Chen Wei,Pin-Yuan Chen,Po-Hung Hsu,Po-Chun Chu,Wen-Yen Chai,Chung-Yin Lin
申请号：
US14822896
公开号：
US10076652B2
申请日:
2015.08.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods to use medical imaging to monitor the molecule penetration into CNS during ultrasound-mediated delivery are disclosed. The method states a two-step process to predict the amount of molecular penetration which is based on the observation of medical imaging. The first is to propose a unified exposure input to unify the exposure condition so as to build a transferred relation to imaging index. The second is to propose a unified imaging index to unify the imaging readout so as to build a reliable transferred relation to molecular concentration. Linking these two, the molecular penetration induced by ultrasound irradiation can be estimated from medical imaging with ultrasound exposure conditions and molecular sizes.
