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Amino alcoholic lipidoids and uses thereof
专利权人:
Massachusetts Institute of Technology
发明人:
MAHON, Kerry Peter,LOVE, Kevin Thomas,LEVINS, Christopher G.,WHITEHEAD, Kathryn Ann,LANGER, Robert S.,ANDERSON, Daniel Griffith
申请号:
ES09825132
公开号:
ES2646630T3
申请日:
2009.11.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula: ** Formula ** in which: p and m are each 1; RA is hydrogen; a cyclic or acyclic C1-20 aliphatic group, branched or unbranched, substituted or unsubstituted; a cyclic or acyclic C1-20 heteroaliphatic group, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl aryl; substituted or unsubstituted heteroaryl; ** Formula ** RF is each presence of R5 is independently hydrogen; a cyclic or acyclic C1-20 aliphatic group, branched or unbranched, substituted or unsubstituted; a cyclic or acyclic C1-20 heteroaliphatic group, branched or unbranched, substituted or unsubstituted; substituted or unsubstituted aryl; or substituted or unsubstituted heteroaryl; ** Formula ** wherein at least one of RY and RZ is each presence of x is an integer between 1 and 10, inclusive; preferably where x is 1, 2 or 3; and is an integer between 1 and 10, inclusive; preferably where y is 1, 2 or 3 preferably where x is 1, and y is 2; or preferably where x is 1 and y is 3; each presence of RY is hydrogen; a cyclic or acyclic C1-20 aliphatic group, branched or unbranched, substituted or unsubstituted; a cyclic or acyclic C1-20 heteroaliphatic group, branched or unbranched, substituted or unsubstituted; ** Formula ** substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; each presence of RZ is hydrogen; a cyclic or acyclic C1-20 aliphatic group, branched or unbranched, substituted or unsubstituted; a cyclic or acyclic C1-20 heteroaliphatic group, branched or unbranched, substituted or unsubstituted; ** Formula ** substituted or unsubstituted aryl; substituted or unsubstituted heteroaryl; or a pharmaceutically acceptable salt thereof. ** Formula **A compuesto of formula:**Fórmula** en el que: p y m are cada uno 1; RA es hidrógeno; un grupo alifático C1-20 cíclico o acíclico, ramificado o no ramificado, sustituido o no sustituido; un grupo heteroalifático C1-20 cíclico o acíclico, ramificado o no ramificado, sustituido o no su
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