The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.本發明關於廣泛中和干擾素-α及干擾素-ω的抗體、編碼該等抗體或片段的聚核苷酸、以及製造與使用上述者之方法。