The present invention relates to antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.本發明關於特異性結合PD-1、TIM-3或PD-1及TIM-3的抗體、編碼該等抗體或片段的聚核苷酸、以及製造與使用上述者之方法。