The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.本發明係有關於一種雙特異性單鏈抗體分子,其包括一個可與人類及非黑猩猩靈長類CD3 ε鏈的表位結合之第一結合域,其中該表位係由序列辨識編號2、4、6與8所組成的群組所包含之胺基酸序列的一部份;及一個可與前列腺特異性膜抗原(PSMA)結合之第二結合域。本發明亦提供編碼該雙特異性單鏈抗體分子的核酸以及載體與宿主細胞,及用於其生產作用之一種方法。本發明進一步有關於包含該雙特異性單鏈抗體分子之藥物組成物,及該雙特異性單鏈抗體分子之醫療用途。
