Roman Kischel;Susanne Mangold;Ralf Lutterbüse;Patrick Hoffmann;Matthias Klinger;Claudia Blümel;Doris Rau;Tobias Raum;Peter Kufer
发明人:
Peter Kufer,Tobias Raum,Roman Kischel,Ralf Lutterbüse,Patrick Hoffmann,Doris Rau,Matthias Klinger,Susanne Mangold,Claudia Blümel
申请号：
US13122242
公开号：
US20120034228A1
申请日:
2009.10.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to an antigen selected from the group consisting of Prostate Stem Cell Antigen (PSCA), B-Lymphocyte antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), Endosialin, the EGF-like domain 1 of EpCAM, encoded by exon 2, Fibroblast activation protein alpha (FAP alpha) and Insulin-like growth factor I receptor (IGF-IR or IGF-1R). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
