The present invention provides compounds of formula (I) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson’s disease. Accordingly, the present invention relates to compounds of formula (Id) wherein R1 is H and R2 is selected from one of the substituents (i) and (ii) below； or R1 is selected from one of the substituents (i) and (ii) below and R2 is H； or R1 and R2 are both represented by substituent (i) below； or R1 and R2 are both represented by substituent (ii) below； or R1 is substituent (i) and R2 is substituent (ii)； or R1 is substituent (ii) and R2 is substituent (i)； wherein * indicates the attachment point； and wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration； or a pharmaceutically acceptable salt thereof.本發明提供了具有式 (I) 之化合物，該等化合物係用於治療神經退行性疾病和障礙的兒茶酚胺之前驅藥。本發明提供了包含本發明化合物之藥物組成物，以及使用本發明化合物治療神經退行性或神經精神性疾病和障礙，特別是帕金森病之方法。因此，本發明涉及具有式 (Id) 之化合物 其中R1係H並且R2選自以下取代基 (i) 和 (ii) 之一；或者R1選自以下取代基 (i) 和 (ii) 之一並且R2係H；或者R1和R2均由以下取代基 (i) 表示；或者R1和R2均由以下取代基 (ii) 表示；或者 R1係取代基 (i) 並且R2係取代基 (ii)；或者R1係取代基 (ii) 並且R2係取代基 (i)； 其中*指示附接點；並且其中在取代基(i)上附接點處的碳原子處於S-組態；或其藥學上可接受的鹽。
