The purpose of present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibition activity. According to the present invention, it is provided the nicotinamide derivatives represented by following general formula (1) or salts thereof.In abovementioned formula, R1 represents a substituent represented by following formulae (II-1), (III-1) or (IV-1)(wherein, R3, R4, R5, n, and X1 have the same meaning as defined in the specification), R2 is pyridyl, indazolyl, phenyl, pyrazopyridyl, benzoisoxazolyl, pyrimidinyl or quinolyl, and optionally has at least one substituent.本發明之目的在於提供具有優異之Syk抑制活性的化合物及醫藥組成物。依照本發明，提供以下列通式(I)表示之菸鹼醯胺衍生物或其鹽。上式中，R1代表以下式(II-1)、(III-1)或(IV-1)表示之取代基(上式中，R3、R4、R5、n、X1與說明書中的定義相同)，R2為也可具有至少1個取代基之吡啶基、吲唑基、苯基、吡唑并吡啶基、苯并異唑基、嘧啶基或喹啉基。
