BAYLOR COLLEGE OF MEDICINE;WILLIAM MARSH RICE UNIVERSITY
发明人:
TOUR, JAMES M.,BEETON, CHRISTINE,HUQ, REDWAN U.,INOUE, TAEKO,PAUTLER, ROBIA G.,SAMUEL, ERROL L. G.
申请号：
CA2923035
公开号：
CA2923035A1
申请日:
2014.09.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
In some embodiments, the present disclosure pertains to methods of treating an inflammatory disease in a subject by administering a carbon material to the subject. In some embodiments, the carbon material selectively targets T cells in the subject. In some embodiments, the carbon material includes poly(ethylene glycol) -functionalized hydrophilic carbon clusters. In some embodiments, the administration of the carbon material to the subject reduces or inhibits T cell-mediated reactions in the subject. In some embodiments, the carbon material selectively targets T cells over other types of immune cells by preferential uptake into the T cells. In some embodiments, the carbon material reduces or inhibits proliferation of targeted T cells, reduces or inhibits cytokine production by targeted T cells, and reduces intracellular oxidant content in targeted T cells. In some embodiments, the present disclosure pertains to methods of modulating T cells ex-vivo by incubating the T cells with a carbon material.
