Samir N. Khleif,Mikayel Mkrtichyan,Iryna Lebedyeva
申请号：
US16416509
公开号：
US20190269672A1
申请日:
2019.05.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Methods of selectively inhibiting Akt3 are provided. It has been discovered that 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide selectively inhibits Akt3. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide can be used for modulating immune responses.
