INGHIRAMI, Giorgio;BERTONI, Francesco;ONCOETHIX SA
发明人:
BERTONI, Francesco,INGHIRAMI, Giorgio
申请号：
EPEP2014/002164
公开号：
WO2015/018521A1
申请日:
2014.08.06
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A method of treating diffuse large B-cell lymphoma comprising administering to a patient a pharmaceutically acceptable amount of a composition comprising a thienotriazolodiazepine compound, said thienotriazolodiazepine compound being represented by Formula (I), wherein R1 is alkyl having a carbon number of 1-4, R2 is a hydrogen atom； a halogen atom； or alkyl having a carbon number of 1-4 optionally substituted by a halogen atom or a hydroxyl group, R3 is a halogen atom； phenyl optionally substituted by a halogen atom, alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4 or cyano； --NR5--(CH2)m--R6 wherein R5 is a hydrogen atom or alkyl having a carbon number of 1-4, m is an integer of 0-4, and R6 is phenyl or pyridyl optionally substituted by a halogen atom； or --NR7--CO--(CH2)n-- R8 wherein R7 is a hydrogen atom or alkyl having a carbon number of 1-4, n is an integer of 0-2, and R8 is phenyl or pyridyl optionally substituted by a halogen atom, and R4 is --(CH2)a--CO--NH--R9 wherein a is an integer of 1-4, and R9 is alkyl having a carbon number of 1-4； hydroxyalkyl having a carbon number of 1-4； alkoxy having a carbon number of 1-4； or phenyl or pyridyl optionally substituted by alkyl having a carbon number of 1-4, alkoxy having a carbon number of 1-4, amino or a hydroxyl group or --(CH2)b--COOR10 wherein b is an integer of 1-4, and R10 is alkyl having a carbon number of 1-4, or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof, wherein the patient has activated B-cell diffuse large B-cell lymphoma.L'invention concerne un procédé de traitement du lymphome diffus à grande cellules B comprenant l'administration à un patient d'une quantité pharmaceutiquement acceptable d'une composition comprenant un composé thiénotriazolodiazépine, ledit composé thiénotriazolodiazépine étant représenté par la formula (I), dans laquelle R1 représente un groupe alkyle ayant un nombre d'atomes de carbone de 1 à 4, R2 représente un atome d'hyd
