National Center for Geriatrics and Gerontology;The Doshisha
发明人:
申请号：
EP12837822.1
公开号：
EP2764863A1
申请日:
2012.10.03
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
A tau aggregation inhibitor that can sufficiently reduce tau aggregation in cells is provided. The tau aggregation inhibitor includes a catechol structure-containing compound or a salt thereof, and the catechol structure-containing compound is selected from the group consisting of isoprenaline, dopamine, dobutamine, levodopa, levodopa/carbidopa, trimetoquinol, hexoprenaline, methyldopa, and droxidopa. The catechol structure-containing compound is preferably isoprenaline. Tauopathies to be prevented or treated by the inhibitor include AD, Down's syndrome, Pick's disease, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP).
