INHIBITEUR D'AGRÉGATION DE PROTÉINES TAU

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专利权人:

NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY;THE DOSHISHA

发明人:

TAKASHIMA, AKIHIKO,SOEDA, YOSHIYUKI,OSADA, HIROYUKI,IHARA, YASUO,MIYASAKA, TOMOHIRO,SUGIMOTO, HACHIRO

申请号：

EP12837822

公开号：

EP2764863A4

申请日:

2012.10.03

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

A tau aggregation inhibitor that can sufficiently reduce tau aggregation in cells is provided. The tau aggregation inhibitor includes a catechol structure-containing compound or a salt thereof, and the catechol structure-containing compound is selected from the group consisting of isoprenaline, dopamine, dobutamine, levodopa, levodopa/carbidopa, trimetoquinol, hexoprenaline, methyldopa, and droxidopa. The catechol structure-containing compound is preferably isoprenaline. Tauopathies to be prevented or treated by the inhibitor include AD, Down's syndrome, Pick's disease, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP).

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/