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Immunomodulation by IAP Inhibitors
专利权人:
Novartis AG;Dana-Farber Cancer Institute, Inc.
发明人:
Leigh ZAWEL,Christopher S. STRAUB,Brant G. FIRESTONE,Glenn DRANOFF,Michael DOUGAN
申请号:
US15675987
公开号:
US20170368047A1
申请日:
2017.08.14
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
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