As for this invention, the pyridine - pirijinon derivative general formula (i): (In formula, R1, R2, R3, R4, n and n, V, as for W, Y, Z and Ar as defined in this bill, is.)And it regards the preparation manner of the said derivative and the remedy application of the said derivative.本発明は、一般式(I)のピリジン-ピリジノン誘導体:(式中、R1、R2、R3、R4、n、n’、V、W、Y、Z、Arは本明細書中で定義するとおりである。)、ならびに該誘導体の調製方法および該誘導体の治療応用に関する。