DELTA-4 DESATURASE AND ITS APPLICATION IN THE MANUFACTURE OF MULTI-Saturated FAT ACIDS

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专利权人:

E.I. DUPONT DE NEMOURS AND COMPANY

发明人:

XUE, ZHIXIONG,ZHU, QUINN, QUN

申请号：

DK09726573

公开号：

DK2259674T3

申请日:

2009.04.01

申请国别(地区):

DK

年份:

2014

代理人:

摘要：

Described here are &Dgr；4 desaturases that convert all-cis-7,10,13,16,19-docosapentaenoic acid [&ldquo；DPA&rdquo；； 22:5 &omega；-3] to docosahexaenoic acid [&ldquo；DHA&rdquo；； 22:6 &omega；-3], with secondary activity in converting docosatetraenoic acid [&ldquo；DTA&rdquo；； 22:4 &omega；-6] to all-cis-4,7,10,13,16-docosapentaenoic acid [&ldquo；DPAn-6&rdquo；； 22:5 &omega；-6]. Also, described here are isolated nuclei acid fragments and recombinant constructs comprising such fragments encoding &Dgr；4 desaturases as well as methods of making long chain polyunsaturated fatty acids [&ldquo；PUFAs&rdquo；] using this &Dgr；4 desaturase in oleaginous yeast.

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