Pulmonary disorders in which the GSNO pool or glutathione pool in the lung isdepleted and where reactive oxygen species in lung are increased, are treatedby deliverying into the lung as a gas, agent causing repletion or increase ofthe GSNO pool or protection against toxicity and does so independently ofreaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN,N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO isadministered in addition to other GSNO repleting agent to potentiate theeffect of said agent.
