The device includes a handle configured to be grasped by a user. The handle has a proximal end nearest the user's hand and a distal end opposing the proximal end. The device also includes an applicator with an applicator tip at the distal end of the handle. The applicator tip fits within the depression formed by a skin wrinkle to apply treatment to at least one side wall and bottom area of the wrinkle without applying treatment to surface skin around the wrinkle. The applicator tip may be pre-medicated with medicine, applied to the tip by a user, or provided medication from a chamber in communication with the applicator tip such that the chamber holds medication. Also disclosed is a method for applying wrinkle treatment that includes aligning the applicator tip with the wrinkle and moving the applicator tip along the length of the wrinkle to apply treatment.