A preparation based upon Nifedipine in association with other active principles with eudermal and emollient properties, which act with a marked synergistic and co-adjuvant action, is able to determine a resolution of the muscles responsible for formation of wrinkles, relaxing the facial tension and reducing effectively the depth of the wrinkles. The invention likewise comprises the formulation with a base of micronized Nifedipine and six other active principles for an anti-wrinkle night cream.