Zhou Wang,Joel Byron Nelson,Minh Bao Nguyen,John S. Lazo,Paul A. Johnston,Peter Wipf
申请号：
US15457782
公开号：
US10004730B2
申请日:
2017.03.13
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from:(a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof or(b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of:wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group R21 is an alkanediyl or a substituted alkanediyl a is 0 or 1 c is 0 or 1 X is C or S R22 is a moiety that includes at least one divalent amino radical and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.
