Mikhail A. Chafeev;Timothy S. Daynard;Shisen Wang;Serguei V. Sviridov;Gregory B. Chopiuk;Zaihui Zhang
发明人:
Zaihui Zhang,Timothy S. Daynard,Mikhail A. Chafeev,Shisen Wang,Gregory B. Chopiuk,Serguei V. Sviridov
申请号：
US12977794
公开号：
US08445694B2
申请日:
2010.12.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
