The present invention relates to a novel cromenone derivative compound having heat shock protein 27 (HSP27) inhibitory activity. The composition, a pharmaceutically acceptable salt thereof or a pharmaceutical composition containing the same, of the present invention, induces the formation of a modified HSP27 dimer so as to reduce the formation of a normal HSP27 multimer, thereby inhibiting the function of HSP27 as a chaperone. Therefore, the present invention can be effective in preventing or treating cancer, can reduce heat shock protein 90 (HSP90) and resistance to other anticancer drugs, and can reduce radioresistance.
