Dedov Ivan Ivanovich (RU),Дедов Иван Иванович (RU),Mokrysheva Natalya Georgievna (RU),Мокрышева Наталья Георгиевна (RU),Melnichenko Galina Afanasevna (RU),Мельниченко Галина Афанасьевна (RU),Troshina
申请号：
RU2019145352
公开号：
RU0002732687C1
申请日:
2019.12.31
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to endocrinology, and can be used for selecting a drug-induced pharmacotherapy for non-diabetic hypoglycaemia (NDH). 72-hour fasting test is performed with continuous monitoring of blood glucose concentration. If glucose concentration is reduced to 2.8 mmol/l, the level of insulin, C-peptide, proinsulin, autoantibodies to insulin, IGF1, IGF2 in venous blood is measured. Time (t) is measured from the beginning of the test until the glucose concentration is reduced to value of 2.8 mmol/l. In case t ≥ 9 hours, diagnose the lung ergometry, wherein nutrition is prescribed 6 times a day with inclusion of complex carbohydrates into the diet. If t is within range of 3 <； t <； 9 hours, the patient is diagnosed with moderate-moderate clinical course. Drug treatment is prescribed if observing the following factors during the NDH episode: generalized convulsions, behavioural disorders, including unmotivated aggression, emotional lability, motor excitement, as well as loss of consciousness, to whom； patient's age over 60 years； severe accompanying diseases, including ischemic heart disease, cardiac rhythm disturbance, psychiatric diseases, severe neurological diseases. In the absence of said factors, nutrition is prescribed every 3–4 hours with introduction of complex carbohydrates into the diet. In case t ≤ 3 hours, diagnosing the severe clinical NDH, prescribing drug-induced treatment. Medicated if observing moderate to severe NDH is prescribed depending on measured blood parameters: with insulin content 3 mcU/ml and more, C-peptide 0.6 ng/ml and more, proinsulin 5 pmol/l and more, and insulin antibodies of less than 10 Unit/ml is prescribed diazoxide in an initial dose of 50 mg every 8 hours with NDH of severe course and 50 mg once a day in moderate moderate clinical shock, or somatostatin or glucocorticoid once a day in moderate flow and once in 12 hours in severe； if the insulin content is more than 100 mcU
