GAUDET, Francois,GAUDET FRANCOIS,ATTAR, Ricardo,ATTAR RICARDO,BALDWIN, Eric Thomas,BALDWIN ERIC THOMAS,POWERS, Gordon D.,POWERS GORDON D,CARDOSO, Rosa Maria Fernandes,CARDOSO ROSA MARIA FERNANDES,PILL
申请号：
CL2018000431
公开号：
CL2018000431A1
申请日:
2018.02.16
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to BCMA. Also described are related polynucleotides capable of encoding the provided BCMA-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor BCMA-expressing cancer progression, regression, or stability to determine whether or not a patient should be treated for cancer or to determine whether or not a subject is afflicted with BCMA-expressing cancer and thus may be amenable to treatment with a BCMA-specific anti-cancer therapeutic, such as the multispecific antibodies against BCMA and CD3 described herein.
