John LATHAM,Katie OLSON,Jeffrey T. L. SMITH,Anne Elisabeth Carvalho JENSEN,Ben DUTZAR,Brian KOVACEVICH,León GARCÍA-MARTÍNEZ,Ethan OJALA
申请号：
MX2015001768
公开号：
MX349322B
申请日:
2008.05.21
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.La presente invención se refiere a el uso de un anticuerpo IL-6 antihumano o fragmento de anticuerpo que comprende una cadena ligera variable que comprende l polipéptido de cadena ligera variable de SEQ ID NO: 20 y el polipéptido de cadena pesada variable de SEQ ID NO: 19 para la preparación de un medicamento para tratar artritis reumatoide.
