PROBLEM TO BE SOLVED: To provide a method for efficiently proliferating epithelial somatic stem cells having pluripotency, and others.SOLUTION: This method for producing epithelial somatic stem cells includes the following steps (A) and (B): (A) a step of expressing a gene of protein having activity to pass a G0 phase or G1 phase and transfer to an S phase in a cell group including epithelial somatic stem cells and (B) a step of culturing the cells obtained in the step (A) in the presence of an extracellular growth factor.COPYRIGHT: (C)2013,JPO&INPIT【課題】多分化能を有する上皮系体性幹細胞を効率的に増殖する方法等を提供することを課題とする。【解決手段】以下の工程(A)及び(B)を含む、上皮系体性幹細胞の製造方法:(A)上皮系体性幹細胞を含む細胞群において、G0期又はG1期を通過させS期へと移行させる活性を有するタンパク質の遺伝子を発現させる工程;及び(B)工程(A)で得られた細胞を細胞外増殖因子の存在下で培養する工程。【選択図】なし
