MERCK SHARP and DOHME CORP.;ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI;MEMORIAL SLOAN KETTERING CANCER CENTER
发明人:
PALESE, Peter,GARCIA-SASTRE, Adolfo,ZAMARIN, Dmitriy,SADEKOVA, Svetlana,ALTURA, Rachel Allison,PHAN, Uyen,HAINES, Brian B.,WOLCHOK, Jedd D.
申请号：
PH12019550229
公开号：
PH12019550229A1
申请日:
2019.11.05
申请国别(地区):
PH
年份:
2020
代理人:
摘要：
Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 ("PD-1") or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.
