Memorial Sloan Kettering Cancer Center;Merck Sharp &； Dohme Corp.;Icahn School of Medicine at Mount Sinai
发明人:
Peter Palese,Adolfo Garcia-Sastre,Dmitriy Zamarin,Svetlana Sadekova,Rachel Allison Altura,Uyen Phan,Brian B. Haines,Jedd D. Wolchok
申请号：
US16611813
公开号：
US20200061184A1
申请日:
2018.05.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.
