PURPOSE: A medical devices with coatings is provided to improve anti-thrombotic action and restenosis by chemically fixing an antibody.CONSTITUTION: A medical devices with coatings is constituted as follows. An antibody against antigen is chemically fixed to a support layer in which bio compatibility/hydrophilic polymer is combined. The antibody is fixed through a silane coupling agent of the chemical formula X-(CH2)n-Si-(Y)m. In the chemical formula, X is selected from a functional group consisting of amine radical, halide radical, epoxy radical, aldehyde radical, and acetal radical, and Y is selected from halide radical, methoxy radical, and ethoxy radical. The metal is stainless metal, nickel-chromium alloy, nickel-titanium alloy, tantalum, or titanium.COPYRIGHT KIPO 2012혈과내피세포를 항원으로 인식, 이에 결합 및/또는 이와 상호작용하여 장치의 표면에 이 세포를 고정하는 항체, 항체 단편 또는 소형 분자를 포함하는 생체적합성 매트릭스로 코팅된, 스텐트, 스텐트 이식편, 합성 혈관 이식편, 심장 밸브와 같은 의료 장치를 제조하기 위한 조성물 및 방법.
