Compound having the formula ** Formula ** or a pharmaceutically acceptable salt or hydrate thereof, wherein X1 is selected from the group consisting of NR ', O and S； X2 is selected from the group consisting of CH2, NR ', O and S； R1 is selected from the group consisting of -OR ', - SR', - NR'R '', -NO2, -CN, -C (O) R ', -C (O) OR', -C (O) NR'R ', - C (NR') NR'R ', trihalomethyl, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl； each R 'is independently selected from the group consisting of -H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl； R2, R3, R4 and R5 are independently selected from the group consisting of H, -OR ', - SR', - NR'R ', -NO2, - CN, -C (O) R', -C (O) OR ', -C (O) NR'R', -C (NR ') NR'R', trihalomethyl, halogen, alkyl, substituted alkyl, heteroalkyl, substituted heteroalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl； each R 'is independently selected from the group consisting of -H, alkyl, heteroalkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl； or R4 and R5 taken together are -CH2- (CH2) n-CH2-, where n is an integer from 0 to 6； or R2 and R3 taken together are -CH2- (CH2) n-CH2-, where n is an integer from 0 to 6； with the proviso that when R1>； = methyl and R2>； = R3>； = R4>； = H, then R5 ¹ benzyl； wherein substituted alkyl, substituted heteroalkyl, substituted alkenyl, substituted alkynyl, substituted aryl, substituted heteroaryl or substituted arylalkyl are an alkyl, heteroalkyl, alkenyl, alkynyl, aryl, heteroaryl or arylalkyl radical, in which one or more of the atoms of hydrogen are independent
